Supermicro Hyper SuperServer SYS-221H-TNR (4x H100 NVL)
Dense 2U Hyper platform balancing GPU acceleration with serviceable enterprise headroom.
We help you choose, configure, and deliver the right system — no obligation.
Configuration at a Glance
Tailored per engagement. Full technical overview below.
Configuration Options
Core specifications for this system. Every component is configurable to your workload — request a quote for a tailored build.
Up to 4x NVIDIA H100 NVL (double-width, configurable)
Dual 5th/4th Gen Intel Xeon Scalable (up to 64C each)
32 DIMM slots, up to 8TB DDR5-5600 ECC RDIMM
8x hot-swap 2.5" NVMe/SAS/SATA + 2x internal M.2
Overview
The Hyper SuperServer SYS-221H-TNR pairs dual 5th Gen Intel Xeon CPUs with up to four double-width NVIDIA GPUs in a serviceable, tool-less 2U chassis built for mixed AI inference and virtualization. Nexus Compute specifies, configures, and tests each system to your accelerator and I/O requirements, delivered warranty-backed through authorized Supermicro channels.
Who This Solution Is For
Business Benefits
Balanced acceleration
Four double-width GPUs deliver real inference throughput without committing to a dedicated 8-GPU node.
Serviceable density
A tool-less 2U design keeps GPUs, drives, and PSUs hot-swappable for low-downtime maintenance.
Flexible expansion
PCIe 5.0 slots and dual AIOM bays adapt the platform to changing accelerator and fabric needs.
Typical Business Use Cases
Production LLM and vision inference serving
GPU-accelerated virtual desktop infrastructure
Mixed AI and enterprise application hosting
Software-defined storage with acceleration
Industry Applications
Technical Overview
Built on Supermicro's X13 Hyper architecture with the Intel C741 chipset, the SYS-221H-TNR supports dual Socket E (LGA-4677) Xeon processors, 32 DDR5 DIMM slots, and up to four double-width GPUs across PCIe 5.0 slots. Dual counter-rotating cooling zones and Titanium redundant power sustain accelerators under continuous inference load.
| GPU/Accelerator | Up to 4x NVIDIA H100 NVL (double-width, configurable) |
| CPU | Dual 5th/4th Gen Intel Xeon Scalable (up to 64C each) |
| Memory | 32 DIMM slots, up to 8TB DDR5-5600 ECC RDIMM |
| Storage | 8x hot-swap 2.5" NVMe/SAS/SATA + 2x internal M.2 |
| Networking/Fabric | Dual AIOM (OCP NIC 3.0); 25/100GbE configurable |
| Form Factor | 2U rackmount, tool-less |
| Management | IPMI 2.0 / Redfish, dedicated BMC LAN |
| Power | Redundant Titanium-level PSUs |
| Warranty | Manufacturer-backed, authorized channel |
Specifications are indicative and configured to each engagement. Request a quote for a configuration tailored to your requirements.
Warranty, Support & Fulfillment
Every system ships from an authorized channel, configured and tested, with the documentation enterprise buyers need — backed by warranty and a dedicated account team.
Enterprise Warranty
Full manufacturer warranty with optional on-site, next-business-day support and extended coverage.
Authorized Channel
Sourced through Tier-1 distribution and OEM partners — never grey market. Asset & warranty records included.
Lead Time & Deployment
48-hour quotes, then configured, burn-in tested, and delivered on a committed schedule.
Nationwide Fulfillment
Coordinated logistics, rack-and-stack, and delivery wherever your infrastructure lives.
Frequently Asked Questions
How many GPUs fit, and which models?
The chassis accepts up to four double-width accelerators such as the H100 NVL or L40S, or up to eight single-width cards. We size the count to your power and thermal envelope and configure accordingly.
Is this better for training or inference?
It is optimized for high-throughput inference, GPU virtualization, and mixed workloads. For large-scale training, an 8-GPU NVLink platform is the better fit, and we can advise on the trade-off.
Does it support standard enterprise networking?
Yes. Dual OCP NIC 3.0 AIOM slots support 25/100GbE, with InfiniBand available when the workload calls for it.
Hardware Assistance
Configure the Supermicro Hyper SuperServer SYS-221H-TNR (4x H100 NVL) with Nexus Compute
Tell us your requirements and a hardware specialist will help you specify, configure, and quote the right system — typically within two business days. No obligation.